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| Name: |
Opaleye Management Inc. |
| City: |
Cambridge |
| State: |
MA |
| Zip: |
02140 |
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 |
Ticker |
Company Name |
Position
Rank |
New/Closed
Postion |
Last
Close |
Value |
Shares Held |
% of
Portfolio |
Value
Change |
Change In
Shares Held |
% of Company |
Industry |
|
OCUL |
Ocular Therapeutix, Inc |
1 |
- |
$0.00 |
$60,544,000 |
6,653,138 |
13.29% |
33,472,000 |
583,138 |
6.036 |
N/A |
|
|
HROW |
Harrow Health Inc |
2 |
- |
$18.17 |
$51,870,000 |
3,920,600 |
11.38% |
9,086,000 |
100,600 |
15.226 |
Biotechnology |
|
|
TGTX |
TG Therapeutics Inc |
3 |
- |
$15.85 |
$34,679,000 |
2,280,000 |
7.61% |
-3,153,000 |
65,000 |
1.769 |
Drug Manufacturers - ... |
|
|
KROS |
Keros Therapeutics, Inc. |
4 |
- |
$0.00 |
$24,329,000 |
367,500 |
5.34% |
10,115,000 |
10,000 |
1.082 |
N/A |
|
|
RYTM |
Rhythm Pharmaceuticals, Inc. |
5 |
- |
$39.97 |
$22,315,000 |
515,000 |
4.9% |
-5,727,000 |
-95,000 |
0.726 |
N/A |
|
|
CPRX |
Catalyst Pharmaceutical Par... |
6 |
- |
$15.62 |
$16,009,000 |
1,004,355 |
3.51% |
-5,427,000 |
-252,845 |
0.969 |
Drugs - Generic |
|
|
ARVN |
Arvinas Holding Company, Llc |
7 |
- |
$26.69 |
$13,622,000 |
330,000 |
2.99% |
2,768,000 |
66,300 |
0.48 |
N/A |
|
|
IOVA |
Iovance Biotherapeutics Inc |
8 |
- |
$7.78 |
$13,294,000 |
897,000 |
2.92% |
6,001,000 |
0 |
0.419 |
N/A |
|
|
JSPR |
Jasper Therapeutics Ord Shs |
9 |
- |
$15.12 |
$12,788,000 |
435,573 |
2.81% |
9,644,000 |
-3,549,767 |
0.429 |
N/A |
|
|
EWTX |
Edgewise Therapeutics, Inc. |
10 |
- |
$0.00 |
$12,130,000 |
665,000 |
2.66% |
4,483,000 |
-34,000 |
0.721 |
N/A |
|
|
APLT |
Applied Therapeutics Inc. |
11 |
- |
$0.00 |
$12,036,000 |
1,770,000 |
2.64% |
8,376,000 |
677,500 |
2.292 |
N/A |
|
|
FDMT |
4d Molecular Therapeutics Inc. |
12 |
- |
$0.00 |
$10,964,000 |
344,123 |
2.41% |
4,714,000 |
35,623 |
0.697 |
N/A |
|
|
CDXS |
Codexis Inc |
13 |
- |
$3.26 |
$10,889,000 |
3,120,000 |
2.39% |
1,600,000 |
74,475 |
4.809 |
Biotechnology |
|
|
TARA |
Protara Therapeutics, Inc |
14 |
- |
$2.67 |
$10,797,000 |
2,692,594 |
2.37% |
5,748,000 |
0 |
25.619 |
N/A |
|
|
SLRN |
Acelyrin, Inc. |
15 |
- |
$4.46 |
$10,665,000 |
1,580,000 |
2.34% |
-20,265,000 |
-2,566,138 |
1.626 |
N/A |
|
|
CRNX |
Crinetics Pharmaceuticals, ... |
16 |
- |
$44.71 |
$9,830,000 |
210,000 |
2.16% |
-1,111,000 |
-97,500 |
0.286 |
N/A |
|
|
ETON |
Eton Pharmaceuticals, Inc. |
17 |
- |
$0.00 |
$9,172,000 |
2,445,781 |
2.01% |
-1,909,000 |
-84,106 |
13.889 |
N/A |
|
|
TRVI |
Trevi Therapeutics, Inc. |
18 |
- |
$0.00 |
$9,125,000 |
2,645,000 |
2% |
5,728,000 |
110,000 |
4.414 |
N/A |
|
|
LYEL |
Lyell Immunopharma, Inc. |
19 |
New |
$2.43 |
$7,482,000 |
3,355,000 |
1.64% |
7,482,000 |
3,355,000 |
1.382 |
N/A |
|
|
NAMS |
Newamsterdam Pharma Ord Shs |
20 |
- |
$0.00 |
$7,459,000 |
315,388 |
1.64% |
4,495,000 |
50,000 |
0.387 |
N/A |
|
|
VTYX |
Ventyx Biosciences, Inc. |
21 |
- |
$3.26 |
$7,068,000 |
1,285,000 |
1.55% |
4,252,000 |
145,000 |
2.555 |
N/A |
|
|
NTLA |
Intellia Therapeutics, Inc. |
22 |
- |
$22.73 |
$7,015,000 |
255,000 |
1.54% |
3,996,000 |
156,000 |
0.285 |
N/A |
|
|
CMPX |
Compass Therapeutics Ord Shs |
23 |
New |
$0.00 |
$6,277,000 |
3,170,000 |
1.38% |
6,277,000 |
3,170,000 |
3.234 |
N/A |
|
|
XOMA |
XOMA Corporation |
24 |
- |
$24.05 |
$6,013,000 |
250,000 |
1.32% |
1,388,000 |
0 |
2.218 |
Biotechnology |
|
|
LQDA |
Liquidia Technologies Inc |
25 |
- |
$13.77 |
$5,826,000 |
395,000 |
1.28% |
473,000 |
-50,000 |
1.046 |
N/A |
|
|
PCVX |
Vaxcyte, Inc. |
26 |
- |
$0.00 |
$5,806,000 |
85,000 |
1.27% |
154,000 |
-5,000 |
0.079 |
N/A |
|
|
NYXH |
Nyxoah Ord Shs |
27 |
- |
$0.00 |
$4,317,000 |
320,000 |
0.95% |
2,717,000 |
-24,800 |
1.252 |
N/A |
|
|
SVRA |
Savara Inc |
28 |
New |
$3.96 |
$4,258,000 |
855,000 |
0.93% |
4,258,000 |
855,000 |
0.632 |
Biotechnology |
|
|
SYRS |
Syros Pharmaceuticals, Inc. |
29 |
- |
$5.15 |
$4,213,000 |
787,545 |
0.92% |
1,414,000 |
428,175 |
1.401 |
N/A |
|
|
URGN |
Urogen Pharma Ltd. |
30 |
- |
$13.21 |
$4,050,000 |
270,000 |
0.89% |
-750,000 |
-50,000 |
1.222 |
N/A |
|
|
NRIX |
Nurix Therapeutics, Inc. |
31 |
New |
$0.00 |
$3,928,000 |
267,210 |
0.86% |
3,928,000 |
267,210 |
0.568 |
N/A |
|
|
RVNC |
Revance Therapeutics, Inc. |
32 |
New |
$2.70 |
$3,862,000 |
785,000 |
0.85% |
3,862,000 |
785,000 |
0.954 |
N/A |
|
|
RLMD |
Relmada Therapeutics, Inc. |
33 |
- |
$2.95 |
$3,529,000 |
759,000 |
0.77% |
-102,000 |
-118,000 |
2.737 |
N/A |
|
|
PTGX |
Protagonist Therapeutics, Inc |
34 |
- |
$34.80 |
$3,260,000 |
112,700 |
0.72% |
676,000 |
0 |
0.195 |
N/A |
|
|
ZNTL |
Zentalis Pharmaceuticals, Llc |
35 |
New |
$0.00 |
$3,152,000 |
200,000 |
0.69% |
3,152,000 |
200,000 |
0.236 |
N/A |
|
|
ALLK |
Allakos Inc. |
36 |
New |
$1.16 |
$3,068,000 |
2,435,000 |
0.67% |
3,068,000 |
2,435,000 |
2.858 |
N/A |
|
|
GOSS |
Gossamer Bio Inc |
37 |
- |
$0.55 |
$2,879,000 |
2,440,109 |
0.63% |
158,000 |
-542,091 |
1.083 |
N/A |
|
|
IBIO |
Ibio Ord Shs |
38 |
New |
$0.20 |
$2,761,000 |
680,000 |
0.61% |
2,761,000 |
680,000 |
0.756 |
Drug Manufacturers - ... |
|
|
VSTM |
Verastem, Inc. |
39 |
- |
$3.40 |
$2,495,000 |
211,400 |
0.55% |
774,000 |
0 |
0.838 |
Biotechnology |
|
|
ALGS |
Aligos Therapeutics, Inc. |
40 |
- |
$0.00 |
$1,597,000 |
1,630,000 |
0.35% |
736,000 |
333,000 |
2.264 |
N/A |
|
|
CNTX |
Context Therapeutics Inc. |
41 |
- |
$0.00 |
$1,530,000 |
1,108,357 |
0.34% |
428,000 |
133,357 |
6.944 |
N/A |
|
|
PGEN |
Precigen Inc |
42 |
- |
$1.62 |
$1,374,000 |
947,500 |
0.3% |
17,000 |
-65,000 |
0.531 |
Biotechnology |
|
|
LRMR |
Larimar Therapeutics Inc |
43 |
- |
$1.15 |
$1,324,000 |
174,413 |
0.29% |
-1,513,000 |
-449,087 |
0.437 |
N/A |
|
|
FULC |
Fulcrum Therapeutics, Inc. |
44 |
- |
$0.00 |
$1,227,000 |
130,000 |
0.27% |
349,000 |
0 |
0.206 |
N/A |
|
|
MOR |
Morphosys Ag |
45 |
- |
$17.95 |
$1,179,000 |
65,000 |
0.26% |
-257,000 |
-80,000 |
0.05 |
N/A |
|
|
GKOS |
Glaukos Corp |
46 |
New |
$113.91 |
$809,000 |
8,576 |
0.18% |
809,000 |
8,576 |
0.016 |
N/A |
|
|
PMVP |
Pmv Pharmaceuticals, Inc. |
47 |
New |
$0.00 |
$802,000 |
471,481 |
0.18% |
802,000 |
471,481 |
0.867 |
N/A |
|
|
BDSX |
Biodesix Inc |
48 |
- |
$0.00 |
$765,000 |
534,657 |
0.17% |
-2,846,000 |
38,157 |
2.015 |
N/A |
|
|
RGLS |
Regulus Therapeutics Inc. |
49 |
New |
$2.23 |
$490,000 |
170,308 |
0.11% |
490,000 |
170,308 |
0.117 |
Biotechnology |
|
|
DSGN |
Design Therapeutics, Inc. |
50 |
New |
$0.00 |
$456,000 |
113,038 |
0.1% |
456,000 |
113,038 |
0.203 |
N/A |
|
|
RPTX |
Repare Therapeutics Inc. |
51 |
New |
$0.00 |
$318,000 |
67,561 |
0.07% |
318,000 |
67,561 |
0.184 |
N/A |
|
|
ARQT |
Arcutis Biotherapeutics, Inc. |
52 |
Closed |
$7.24 |
$0 |
0 |
0% |
-6,331,000 |
-1,960,000 |
0 |
N/A |
|
|
STRO |
Sutro Biopharma Inc |
56 |
Closed |
$3.71 |
$0 |
0 |
0% |
-1,293,000 |
-301,491 |
0 |
N/A |
|
|
IDYA |
Ideaya Biosciences, Inc. |
58 |
Closed |
$0.00 |
$0 |
0 |
0% |
-11,083,000 |
-311,500 |
0 |
N/A |
|
|
BHVN |
Biohaven Ltd. |
57 |
Closed |
$33.64 |
$0 |
0 |
0% |
-8,560,000 |
-200,000 |
0 |
N/A |
|
|
KNSA |
Kiniksa Pharmaceuticals, Ltd. |
53 |
Closed |
$19.06 |
$0 |
0 |
0% |
-640,000 |
-37,500 |
0 |
N/A |
|
|
KALV |
Kalvista Pharmaceuticals Inc |
54 |
Closed |
$11.68 |
$0 |
0 |
0% |
-1,838,000 |
-150,000 |
0 |
N/A |
|
|
MRNS |
Marinus Pharmaceuticals Inc |
55 |
Closed |
$1.52 |
$0 |
0 |
0% |
-6,125,000 |
-563,500 |
0 |
N/A |
|
