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ORBIMED ADVISORS LLC |
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NEW YORK |
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NY |
Zip: |
10017 |
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Ticker |
Company Name |
Position Rank |
New/Closed Postion |
Last Close |
Value |
Shares Held |
% of Portfolio |
Value Change |
Change In Shares Held |
% of Company |
Industry |
|
EWTX |
Edgewise Therapeutics, Inc. |
1 |
- |
$31.95 |
$400,930,000 |
15,021,721 |
7.34% |
130,389,000 |
0 |
14.563 |
N/A |
|
SVA |
Sinovac Biotech Ltd |
2 |
- |
$6.47 |
$340,000,000 |
2,718,735 |
6.22% |
0 |
0 |
4.892 |
Drug Manufacturers - ... |
|
LLY |
Eli Lilly & Co |
3 |
- |
$753.41 |
$299,093,000 |
337,600 |
5.47% |
-6,563,000 |
0 |
0.035 |
Drug Manufacturers - ... |
|
BSX |
Boston Scientific Corp |
4 |
- |
$90.17 |
$274,277,000 |
3,273,000 |
5.02% |
22,223,000 |
0 |
0.229 |
Medical Instruments &... |
|
ISRG |
Intuitive Surgical Inc |
5 |
- |
$372.63 |
$213,113,000 |
433,800 |
3.9% |
-6,243,000 |
-59,300 |
0.121 |
Medical Appliances & ... |
|
ELVN |
Enliven Therapeutics Ord Shs |
6 |
- |
$0.00 |
$203,287,000 |
7,959,538 |
3.72% |
17,273,000 |
0 |
15.843 |
N/A |
|
BIIB |
Biogen Idec Inc |
7 |
- |
$156.00 |
$157,592,000 |
813,000 |
2.88% |
-51,255,000 |
-87,900 |
0.528 |
Biotechnology |
|
MRK |
Merck & Co Inc |
8 |
- |
$97.44 |
$149,445,000 |
1,316,000 |
2.73% |
-13,476,000 |
0 |
0.052 |
Drug Manufacturers - ... |
|
THC |
Tenet Healthcare Corp |
9 |
- |
$151.84 |
$129,968,000 |
782,000 |
2.38% |
-26,116,000 |
-391,300 |
0.723 |
Hospitals |
|
SYK |
Stryker Corp |
10 |
- |
$385.68 |
$124,418,000 |
344,400 |
2.28% |
32,891,000 |
75,400 |
0.092 |
Medical Instruments &... |
|
SBTX |
Silverback Therapeutics, Inc. |
11 |
- |
$0.00 |
$120,183,000 |
8,288,510 |
2.2% |
41,543,000 |
-952,377 |
4.787 |
N/A |
|
SRPT |
Sarepta Therapeutics Inc |
12 |
- |
$110.86 |
$119,208,000 |
954,500 |
2.18% |
17,140,000 |
308,500 |
1.001 |
Drug Manufacturers - ... |
|
ARGX |
Argenx Se |
13 |
- |
$591.82 |
$110,855,000 |
204,500 |
2.03% |
20,934,000 |
-4,600 |
0.435 |
N/A |
|
UNH |
Unitedhealth Group Inc |
14 |
- |
$600.50 |
$104,658,000 |
179,000 |
1.92% |
47,621,000 |
67,000 |
0.019 |
Health Care Plans |
|
QTTB |
Q32 Bio Inc |
15 |
- |
$27.28 |
$100,528,000 |
2,252,987 |
1.84% |
60,087,000 |
0 |
4.7 |
N/A |
|
MBX |
Mbx Biosciences, Inc. |
16 |
New |
$0.00 |
$99,041,000 |
3,812,215 |
1.81% |
99,041,000 |
3,812,215 |
11.407 |
N/A |
|
IONS |
Ionis Pharmaceuticals Inc |
17 |
- |
$35.40 |
$93,117,000 |
2,324,447 |
1.7% |
-19,948,000 |
-47,886 |
1.62 |
Drug Manufacturers - ... |
|
IRON |
Disc Medicine, Inc |
18 |
- |
$62.55 |
$87,743,000 |
1,785,571 |
1.61% |
7,267,000 |
0 |
6.006 |
N/A |
|
NTRA |
Natera, Inc. |
19 |
- |
$167.88 |
$87,278,000 |
687,500 |
1.6% |
12,829,000 |
0 |
0.556 |
N/A |
|
AMGN |
Amgen Inc |
20 |
- |
$287.87 |
$81,294,000 |
252,300 |
1.49% |
39,144,000 |
117,400 |
0.043 |
Biotechnology |
|
THRD |
Third Harmonic Bio, Inc. |
21 |
- |
$11.62 |
$78,306,000 |
5,779,071 |
1.43% |
3,178,000 |
0 |
14.255 |
N/A |
|
ITGR |
Integer Holdings Corporation |
22 |
- |
$133.37 |
$74,750,000 |
575,000 |
1.37% |
34,314,000 |
225,779 |
1.254 |
Industrial Electrical... |
|
AVBP |
Arrivent Biopharma, Inc. |
23 |
- |
$27.41 |
$71,142,000 |
3,027,328 |
1.3% |
14,985,000 |
0 |
9.04 |
N/A |
|
VRTX |
Vertex Pharmaceuticals Inc |
24 |
- |
$451.23 |
$70,227,000 |
151,000 |
1.29% |
-550,000 |
0 |
0.058 |
Drug Manufacturers - ... |
|
ALNY |
Alnylam Pharmaceuticals Inc |
25 |
- |
$248.79 |
$68,840,000 |
250,300 |
1.26% |
8,017,000 |
0 |
0.203 |
Biotechnology |
|
TERN |
Terns Pharmaceuticals, Inc. |
26 |
- |
$5.60 |
$63,075,000 |
7,562,971 |
1.15% |
11,189,000 |
-56,164 |
11.657 |
N/A |
|
KROS |
Keros Therapeutics, Inc. |
27 |
- |
$0.00 |
$59,158,000 |
1,018,734 |
1.08% |
1,177,000 |
-250,000 |
2.998 |
N/A |
|
JANX |
Janux Therapeutics, Inc. |
28 |
- |
$0.00 |
$57,177,000 |
1,258,566 |
1.05% |
-67,648,000 |
-1,721,262 |
2.413 |
N/A |
|
ANTM |
Anthem Inc |
29 |
- |
$397.48 |
$55,224,000 |
106,200 |
1.01% |
-35,863,000 |
-61,900 |
0.042 |
N/A |
|
CRNX |
Crinetics Pharmaceuticals, ... |
30 |
- |
$56.07 |
$53,658,000 |
1,050,055 |
0.98% |
-3,709,000 |
-230,745 |
1.271 |
N/A |
|
TMO |
Thermo Fisher Scientific |
31 |
- |
$512.84 |
$52,207,000 |
84,400 |
0.96% |
-20,789,000 |
-47,600 |
0.021 |
Medical Laboratories ... |
|
XTNT |
Xtant Medical Holdings Inc |
32 |
- |
$0.41 |
$49,425,000 |
73,114,592 |
0.9% |
3,363,000 |
0 |
56.194 |
Biotechnology |
|
RNA |
Avidity Biosciences, Inc. |
33 |
- |
$43.65 |
$47,988,000 |
1,044,805 |
0.88% |
19,128,000 |
338,330 |
0.892 |
N/A |
|
REGN |
Regeneron Pharmaceuticals Inc |
34 |
- |
$743.35 |
$47,516,000 |
45,200 |
0.87% |
23,553,000 |
22,400 |
0.043 |
Biotechnology |
|
EVH |
Evolent Health, Inc. |
35 |
- |
$11.31 |
$47,089,000 |
1,665,115 |
0.86% |
-2,730,000 |
-940,500 |
1.26 |
N/A |
|
EXAS |
Exact Sciences Corp |
36 |
- |
$52.70 |
$46,309,000 |
679,816 |
0.85% |
17,899,000 |
7,400 |
0.383 |
Biotechnology |
|
SIBN |
Si-Bone, Inc. |
37 |
- |
$0.00 |
$46,215,000 |
3,305,801 |
0.85% |
4,451,000 |
75,824 |
7.929 |
N/A |
|
SWTX |
Springworks Therapeutics, Inc. |
38 |
- |
$0.00 |
$44,556,000 |
1,390,631 |
0.82% |
-19,759,000 |
-316,700 |
1.754 |
N/A |
|
PCVX |
Vaxcyte, Inc. |
39 |
- |
$0.00 |
$44,222,000 |
387,000 |
0.81% |
-15,876,000 |
-408,900 |
0.298 |
N/A |
|
CMPX |
Compass Therapeutics Ord Shs |
40 |
- |
$0.00 |
$41,148,000 |
22,362,850 |
0.75% |
18,785,000 |
0 |
22.812 |
N/A |
|
CYTK |
Cytokinetics Inc |
41 |
- |
$49.86 |
$40,493,000 |
766,906 |
0.74% |
-3,550,000 |
-46,000 |
0.559 |
Biotechnology |
|
SNDX |
Syndax Pharmaceuticals Inc |
42 |
- |
$15.95 |
$37,062,000 |
1,925,300 |
0.68% |
-2,464,000 |
0 |
2.048 |
N/A |
|
CRVS |
Corvus Pharmaceuticals, Inc. |
43 |
- |
$8.24 |
$36,662,000 |
6,943,654 |
0.67% |
24,025,000 |
0 |
24.763 |
N/A |
|
APLS |
Apellis Pharmaceuticals Inc |
44 |
- |
$27.49 |
$36,638,000 |
1,270,400 |
0.67% |
-13,337,000 |
-32,400 |
1.11 |
N/A |
|
XENE |
Xenon Pharmaceuticals Inc. |
45 |
- |
$0.00 |
$35,883,000 |
911,420 |
0.66% |
2,260,000 |
49,058 |
1.211 |
N/A |
|
UHS |
Universal Health Services Inc |
46 |
New |
$197.52 |
$35,726,000 |
156,000 |
0.65% |
35,726,000 |
156,000 |
0.201 |
Hospitals |
|
ICLR |
ICON plc (ADR) |
47 |
- |
$203.67 |
$35,598,000 |
123,900 |
0.65% |
-18,977,000 |
-50,200 |
0.156 |
Research Services |
|
NBIX |
Neurocrine Biosciences Inc |
48 |
- |
$123.29 |
$34,822,000 |
302,220 |
0.64% |
-26,882,000 |
-145,980 |
0.323 |
Biotechnology |
|
VERA |
Vera Therapeutics, Inc. |
49 |
- |
$0.00 |
$29,874,000 |
675,872 |
0.55% |
5,421,000 |
0 |
1.233 |
N/A |
|
BIOA |
Bioage Labs, Inc. |
50 |
New |
$18.40 |
$29,608,000 |
1,423,470 |
0.54% |
29,608,000 |
1,423,470 |
3.974 |
N/A |
|
SCPH |
Scpharmaceuticals Inc. |
51 |
- |
$0.00 |
$27,631,000 |
6,059,528 |
0.51% |
3,447,000 |
500,000 |
18.557 |
N/A |
|
VIR |
Vir Biotechnology, Inc. |
52 |
- |
$0.00 |
$26,762,000 |
3,573,000 |
0.49% |
6,113,000 |
1,252,898 |
2.805 |
N/A |
|
PHAT |
Phathom Pharmaceuticals, Inc. |
53 |
New |
$0.00 |
$26,199,000 |
1,449,073 |
0.48% |
26,199,000 |
1,449,073 |
2.531 |
N/A |
|
CGON |
CG Oncology, Inc |
54 |
New |
$32.24 |
$26,076,000 |
691,114 |
0.48% |
26,076,000 |
691,114 |
1.047 |
N/A |
|
DYN |
Dyne Therapeutics, Inc. |
55 |
- |
$29.99 |
$25,446,000 |
708,400 |
0.47% |
447,000 |
0 |
0.614 |
N/A |
|
CCCC |
C4 Therapeutics, Inc. |
56 |
- |
$0.00 |
$24,954,000 |
4,377,900 |
0.46% |
17,964,000 |
2,864,842 |
6.314 |
N/A |
|
MLYS |
Mineralys Therapeutics, Inc. |
57 |
- |
$0.00 |
$24,256,000 |
2,002,939 |
0.44% |
605,000 |
-18,485 |
4.028 |
N/A |
|
NPCE |
Neuropace Inc |
58 |
- |
$9.19 |
$23,742,000 |
3,406,335 |
0.43% |
-2,010,000 |
0 |
14.024 |
N/A |
|
IMTX |
Immatics N.V |
59 |
- |
$7.80 |
$22,893,000 |
2,006,381 |
0.42% |
-421,000 |
0 |
1.946 |
N/A |
|
RYTM |
Rhythm Pharmaceuticals, Inc. |
60 |
- |
$59.36 |
$22,837,000 |
435,900 |
0.42% |
-6,104,000 |
-268,942 |
0.615 |
N/A |
|
PRLD |
Prelude Therapeutics Inc |
61 |
- |
$0.00 |
$22,582,000 |
10,909,256 |
0.41% |
-18,982,000 |
0 |
24.964 |
N/A |
|
APGE |
Apogee Therapeutics, Inc. |
62 |
- |
$45.04 |
$22,270,000 |
379,130 |
0.41% |
7,351,000 |
0 |
0.648 |
N/A |
|
NMRA |
Neumora Therapeutics, Inc. |
63 |
- |
$9.79 |
$19,815,000 |
1,500,000 |
0.36% |
5,070,000 |
0 |
0.982 |
N/A |
|
SLRN |
Acelyrin, Inc. |
64 |
- |
$4.43 |
$19,728,000 |
4,001,711 |
0.36% |
2,080,000 |
0 |
4.117 |
N/A |
|
CRBP |
Corbus Pharmaceuticals Hold... |
65 |
New |
$16.08 |
$18,826,000 |
912,552 |
0.34% |
18,826,000 |
912,552 |
0.728 |
N/A |
|
TYRA |
Tyra Biosciences, Inc. |
66 |
- |
$0.00 |
$18,071,000 |
768,638 |
0.33% |
5,780,000 |
0 |
1.457 |
N/A |
|
CGEM |
Cullinan Oncology Ord Shs |
67 |
- |
$0.00 |
$17,913,000 |
1,070,055 |
0.33% |
-2,102,000 |
-77,600 |
0.246 |
N/A |
|
LXRX |
Lexicon Pharmaceuticals Inc |
68 |
- |
$0.81 |
$17,308,000 |
11,024,000 |
0.32% |
7,487,000 |
5,177,900 |
3.05 |
Diagnostic Substances |
|
GPCR |
Structure Therapeutics Inc. |
69 |
- |
$32.71 |
$16,841,000 |
383,705 |
0.31% |
11,932,000 |
258,705 |
0.64 |
N/A |
|
ACET |
Adicet Bio, Inc |
70 |
- |
$0.97 |
$16,484,000 |
11,447,140 |
0.3% |
2,633,000 |
0 |
13.892 |
N/A |
|
MEDP |
Medpace Holdings, Inc. |
71 |
New |
$326.09 |
$14,988,000 |
44,900 |
0.27% |
14,988,000 |
44,900 |
0.127 |
N/A |
|
ADCT |
ADC Therapeutics Sa |
72 |
- |
$1.98 |
$14,281,000 |
4,533,801 |
0.26% |
640,000 |
216,977 |
6.41 |
N/A |
|
GILD |
Gilead Sciences Inc |
73 |
New |
$88.63 |
$12,719,000 |
151,700 |
0.23% |
12,719,000 |
151,700 |
0.012 |
Biotechnology |
|
BNTX |
Biontech Se Adr |
74 |
New |
$0.00 |
$12,233,000 |
103,000 |
0.22% |
12,233,000 |
103,000 |
0.043 |
N/A |
|
ACAD |
Acadia Pharmaceuticals Inc |
75 |
New |
$16.27 |
$11,760,000 |
764,600 |
0.22% |
11,760,000 |
764,600 |
0.476 |
Biotechnology |
|
RPTX |
Repare Therapeutics Inc. |
76 |
- |
$0.00 |
$11,429,000 |
3,322,488 |
0.21% |
465,000 |
0 |
9.041 |
N/A |
|
ABCL |
Abcellera Biologics Inc. |
77 |
- |
$0.00 |
$10,870,000 |
4,180,768 |
0.2% |
-1,505,000 |
0 |
1.553 |
N/A |
|
PMVP |
Pmv Pharmaceuticals, Inc. |
78 |
- |
$0.00 |
$9,648,000 |
6,475,291 |
0.18% |
-842,000 |
0 |
11.904 |
N/A |
|
AVTX |
Avalo Therapeutics, Inc |
79 |
New |
$0.43 |
$9,187,000 |
967,000 |
0.17% |
9,187,000 |
967,000 |
0.861 |
N/A |
|
VSTM |
Verastem, Inc. |
80 |
- |
$3.79 |
$8,559,000 |
2,862,448 |
0.16% |
4,002,000 |
1,333,333 |
11.345 |
Biotechnology |
|
LYEL |
Lyell Immunopharma, Inc. |
81 |
- |
$1.03 |
$8,399,000 |
6,086,001 |
0.15% |
-888,000 |
-319,097 |
2.506 |
N/A |
|
OSCR |
Oscar Health, Inc. |
82 |
New |
$0.00 |
$7,458,000 |
351,618 |
0.14% |
7,458,000 |
351,618 |
0.146 |
N/A |
|
BCAX |
Bicara Therapeutics Inc. |
83 |
New |
$18.38 |
$6,926,000 |
271,910 |
0.13% |
6,926,000 |
271,910 |
0.5 |
N/A |
|
PASG |
Passage Bio, Inc. |
84 |
- |
$0.51 |
$6,876,000 |
9,822,876 |
0.13% |
-1,165,000 |
-301,700 |
21.575 |
N/A |
|
PEPG |
Pepgen Inc. |
85 |
New |
$4.40 |
$6,817,000 |
797,358 |
0.12% |
6,817,000 |
797,358 |
2.447 |
N/A |
|
NKTX |
Nkarta, Inc. |
86 |
- |
$0.00 |
$6,692,000 |
1,480,600 |
0.12% |
1,964,000 |
680,600 |
2.098 |
N/A |
|
IKNA |
Ikena Oncology, Inc. |
87 |
- |
$0.00 |
$6,123,000 |
3,539,358 |
0.11% |
283,000 |
0 |
7.334 |
N/A |
|
FOLD |
Amicus Therapeutics Inc |
88 |
- |
$10.61 |
$6,091,000 |
570,300 |
0.11% |
434,000 |
0 |
0.168 |
Biotechnology |
|
SRRK |
Scholar Rock Holding Corp |
89 |
- |
$27.86 |
$5,946,000 |
742,300 |
0.11% |
-3,004,000 |
-332,082 |
0.857 |
N/A |
|
FATE |
Fate Therapeutics Inc |
90 |
- |
$2.22 |
$5,882,000 |
1,680,580 |
0.11% |
1,436,000 |
325,228 |
1.013 |
Biotechnology |
|
NSPR |
Inspiremd, Inc |
91 |
- |
$0.00 |
$5,718,000 |
2,133,405 |
0.1% |
395,000 |
0 |
9.9 |
N/A |
|
LBPH |
Longboard Pharmaceuticals, ... |
92 |
New |
$0.00 |
$5,666,000 |
170,000 |
0.1% |
5,666,000 |
170,000 |
0.437 |
N/A |
|
TELA |
Tela Bio, Inc. |
93 |
- |
$2.90 |
$5,468,000 |
2,161,185 |
0.1% |
-6,082,000 |
-296,357 |
8.825 |
N/A |
|
XFOR |
X4 Pharmaceuticals Inc |
94 |
- |
$0.34 |
$4,774,000 |
7,133,515 |
0.09% |
637,000 |
0 |
4.264 |
N/A |
|
KRYS |
Krystal Biotech Inc |
95 |
- |
$178.10 |
$4,278,000 |
23,500 |
0.08% |
-1,225,000 |
-6,466 |
0.082 |
N/A |
|
ARDT |
Ardent Health Partners, Inc. |
96 |
New |
$16.44 |
$3,786,000 |
206,000 |
0.07% |
3,786,000 |
206,000 |
0.144 |
N/A |
|
TRAW |
Traws Pharma, Inc |
97 |
- |
$4.49 |
$3,561,000 |
605,531 |
0.07% |
3,094,000 |
-439,730 |
12.111 |
N/A |
|
MIST |
Milestone Pharmaceuticals Inc. |
98 |
- |
$0.00 |
$3,040,000 |
2,000,000 |
0.06% |
400,000 |
0 |
3.022 |
N/A |
|
CMMB |
Chemomab Therapeutics Ameri... |
99 |
- |
$0.00 |
$2,734,000 |
1,741,273 |
0.05% |
689,000 |
-500,000 |
25.532 |
N/A |
|
TIL |
Instil Bio Ord Shs |
100 |
New |
$0.00 |
$2,269,000 |
33,700 |
0.04% |
2,269,000 |
33,700 |
0.026 |
N/A |
|