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  Name: ORBIMED ADVISORS LLC
  City: NEW YORK
  State: NY
  Zip: 10017
   
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Portfolio Summary View Filing
  Filing Report Date : 2024-09-30
  Total Value : $5,464,901,000
  Total Value Change : $434,583,000
  Securities Held Change : 1
   
All Securities Held : 109
  New Positions : 17
  Closed Positions : 16
  Increased Positions : 19
  Unchanged Positions : 42
  Decreased Positions : 31

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Holdings Found : 100     View All Holdings Currently Viewing:  ALL     Page 1 of 1
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Ticker Company Name Position
Rank
New/Closed
Postion
Last
Close
    Value Shares Held
% of
Portfolio
Value
Change
Change In
Shares Held
   % of Company    Industry
   (EWTX)1 Year Chart         EWTX Edgewise Therapeutics, Inc. 1 - $31.95 $400,930,000 15,021,721 7.34% 130,389,000 0 14.563    N/A
   (SVA)1 Year Chart         SVA Sinovac Biotech Ltd 2 - $6.47 $340,000,000 2,718,735 6.22% 0 0 4.892    Drug Manufacturers - ...
   (LLY)1 Year Chart         LLY Eli Lilly & Co 3 - $753.41 $299,093,000 337,600 5.47% -6,563,000 0 0.035    Drug Manufacturers - ...
   (BSX)1 Year Chart         BSX Boston Scientific Corp 4 - $90.17 $274,277,000 3,273,000 5.02% 22,223,000 0 0.229    Medical Instruments &...
   (ISRG)1 Year Chart         ISRG Intuitive Surgical Inc 5 - $372.63 $213,113,000 433,800 3.9% -6,243,000 -59,300 0.121    Medical Appliances & ...
   (ELVN)1 Year Chart         ELVN Enliven Therapeutics Ord Shs 6 - $0.00 $203,287,000 7,959,538 3.72% 17,273,000 0 15.843    N/A
   (BIIB)1 Year Chart         BIIB Biogen Idec Inc 7 - $156.00 $157,592,000 813,000 2.88% -51,255,000 -87,900 0.528    Biotechnology
   (MRK)1 Year Chart         MRK Merck & Co Inc 8 - $97.44 $149,445,000 1,316,000 2.73% -13,476,000 0 0.052    Drug Manufacturers - ...
   (THC)1 Year Chart         THC Tenet Healthcare Corp 9 - $151.84 $129,968,000 782,000 2.38% -26,116,000 -391,300 0.723    Hospitals
   (SYK)1 Year Chart         SYK Stryker Corp 10 - $385.68 $124,418,000 344,400 2.28% 32,891,000 75,400 0.092    Medical Instruments &...
   (SBTX)1 Year Chart         SBTX Silverback Therapeutics, Inc. 11 - $0.00 $120,183,000 8,288,510 2.2% 41,543,000 -952,377 4.787    N/A
   (SRPT)1 Year Chart         SRPT Sarepta Therapeutics Inc 12 - $110.86 $119,208,000 954,500 2.18% 17,140,000 308,500 1.001    Drug Manufacturers - ...
   (ARGX)1 Year Chart         ARGX Argenx Se 13 - $591.82 $110,855,000 204,500 2.03% 20,934,000 -4,600 0.435    N/A
   (UNH)1 Year Chart         UNH Unitedhealth Group Inc 14 - $600.50 $104,658,000 179,000 1.92% 47,621,000 67,000 0.019    Health Care Plans
   (QTTB)1 Year Chart         QTTB Q32 Bio Inc 15 - $27.28 $100,528,000 2,252,987 1.84% 60,087,000 0 4.7    N/A
   (MBX)1 Year Chart         MBX Mbx Biosciences, Inc. 16 New $0.00 $99,041,000 3,812,215 1.81% 99,041,000 3,812,215 11.407    N/A
   (IONS)1 Year Chart         IONS Ionis Pharmaceuticals Inc 17 - $35.40 $93,117,000 2,324,447 1.7% -19,948,000 -47,886 1.62    Drug Manufacturers - ...
   (IRON)1 Year Chart         IRON Disc Medicine, Inc 18 - $62.55 $87,743,000 1,785,571 1.61% 7,267,000 0 6.006    N/A
   (NTRA)1 Year Chart         NTRA Natera, Inc. 19 - $167.88 $87,278,000 687,500 1.6% 12,829,000 0 0.556    N/A
   (AMGN)1 Year Chart         AMGN Amgen Inc 20 - $287.87 $81,294,000 252,300 1.49% 39,144,000 117,400 0.043    Biotechnology
   (THRD)1 Year Chart         THRD Third Harmonic Bio, Inc. 21 - $11.62 $78,306,000 5,779,071 1.43% 3,178,000 0 14.255    N/A
   (ITGR)1 Year Chart         ITGR Integer Holdings Corporation 22 - $133.37 $74,750,000 575,000 1.37% 34,314,000 225,779 1.254    Industrial Electrical...
   (AVBP)1 Year Chart         AVBP Arrivent Biopharma, Inc. 23 - $27.41 $71,142,000 3,027,328 1.3% 14,985,000 0 9.04    N/A
   (VRTX)1 Year Chart         VRTX Vertex Pharmaceuticals Inc 24 - $451.23 $70,227,000 151,000 1.29% -550,000 0 0.058    Drug Manufacturers - ...
   (ALNY)1 Year Chart         ALNY Alnylam Pharmaceuticals Inc 25 - $248.79 $68,840,000 250,300 1.26% 8,017,000 0 0.203    Biotechnology
   (TERN)1 Year Chart         TERN Terns Pharmaceuticals, Inc. 26 - $5.60 $63,075,000 7,562,971 1.15% 11,189,000 -56,164 11.657    N/A
   (KROS)1 Year Chart         KROS Keros Therapeutics, Inc. 27 - $0.00 $59,158,000 1,018,734 1.08% 1,177,000 -250,000 2.998    N/A
   (JANX)1 Year Chart         JANX Janux Therapeutics, Inc. 28 - $0.00 $57,177,000 1,258,566 1.05% -67,648,000 -1,721,262 2.413    N/A
   (ANTM)1 Year Chart         ANTM Anthem Inc 29 - $397.48 $55,224,000 106,200 1.01% -35,863,000 -61,900 0.042    N/A
   (CRNX)1 Year Chart         CRNX Crinetics Pharmaceuticals, ... 30 - $56.07 $53,658,000 1,050,055 0.98% -3,709,000 -230,745 1.271    N/A
   (TMO)1 Year Chart         TMO Thermo Fisher Scientific 31 - $512.84 $52,207,000 84,400 0.96% -20,789,000 -47,600 0.021    Medical Laboratories ...
   (XTNT)1 Year Chart         XTNT Xtant Medical Holdings Inc 32 - $0.41 $49,425,000 73,114,592 0.9% 3,363,000 0 56.194    Biotechnology
   (RNA)1 Year Chart         RNA Avidity Biosciences, Inc. 33 - $43.65 $47,988,000 1,044,805 0.88% 19,128,000 338,330 0.892    N/A
   (REGN)1 Year Chart         REGN Regeneron Pharmaceuticals Inc 34 - $743.35 $47,516,000 45,200 0.87% 23,553,000 22,400 0.043    Biotechnology
   (EVH)1 Year Chart         EVH Evolent Health, Inc. 35 - $11.31 $47,089,000 1,665,115 0.86% -2,730,000 -940,500 1.26    N/A
   (EXAS)1 Year Chart         EXAS Exact Sciences Corp 36 - $52.70 $46,309,000 679,816 0.85% 17,899,000 7,400 0.383    Biotechnology
   (SIBN)1 Year Chart         SIBN Si-Bone, Inc. 37 - $0.00 $46,215,000 3,305,801 0.85% 4,451,000 75,824 7.929    N/A
   (SWTX)1 Year Chart         SWTX Springworks Therapeutics, Inc. 38 - $0.00 $44,556,000 1,390,631 0.82% -19,759,000 -316,700 1.754    N/A
   (PCVX)1 Year Chart         PCVX Vaxcyte, Inc. 39 - $0.00 $44,222,000 387,000 0.81% -15,876,000 -408,900 0.298    N/A
   (CMPX)1 Year Chart         CMPX Compass Therapeutics Ord Shs 40 - $0.00 $41,148,000 22,362,850 0.75% 18,785,000 0 22.812    N/A
   (CYTK)1 Year Chart         CYTK Cytokinetics Inc 41 - $49.86 $40,493,000 766,906 0.74% -3,550,000 -46,000 0.559    Biotechnology
   (SNDX)1 Year Chart         SNDX Syndax Pharmaceuticals Inc 42 - $15.95 $37,062,000 1,925,300 0.68% -2,464,000 0 2.048    N/A
   (CRVS)1 Year Chart         CRVS Corvus Pharmaceuticals, Inc. 43 - $8.24 $36,662,000 6,943,654 0.67% 24,025,000 0 24.763    N/A
   (APLS)1 Year Chart         APLS Apellis Pharmaceuticals Inc 44 - $27.49 $36,638,000 1,270,400 0.67% -13,337,000 -32,400 1.11    N/A
   (XENE)1 Year Chart         XENE Xenon Pharmaceuticals Inc. 45 - $0.00 $35,883,000 911,420 0.66% 2,260,000 49,058 1.211    N/A
   (UHS)1 Year Chart         UHS Universal Health Services Inc 46 New $197.52 $35,726,000 156,000 0.65% 35,726,000 156,000 0.201    Hospitals
   (ICLR)1 Year Chart         ICLR ICON plc (ADR) 47 - $203.67 $35,598,000 123,900 0.65% -18,977,000 -50,200 0.156    Research Services
   (NBIX)1 Year Chart         NBIX Neurocrine Biosciences Inc 48 - $123.29 $34,822,000 302,220 0.64% -26,882,000 -145,980 0.323    Biotechnology
   (VERA)1 Year Chart         VERA Vera Therapeutics, Inc. 49 - $0.00 $29,874,000 675,872 0.55% 5,421,000 0 1.233    N/A
   (BIOA)1 Year Chart         BIOA Bioage Labs, Inc. 50 New $18.40 $29,608,000 1,423,470 0.54% 29,608,000 1,423,470 3.974    N/A
   (SCPH)1 Year Chart         SCPH Scpharmaceuticals Inc. 51 - $0.00 $27,631,000 6,059,528 0.51% 3,447,000 500,000 18.557    N/A
   (VIR)1 Year Chart         VIR Vir Biotechnology, Inc. 52 - $0.00 $26,762,000 3,573,000 0.49% 6,113,000 1,252,898 2.805    N/A
   (PHAT)1 Year Chart         PHAT Phathom Pharmaceuticals, Inc. 53 New $0.00 $26,199,000 1,449,073 0.48% 26,199,000 1,449,073 2.531    N/A
   (CGON)1 Year Chart         CGON CG Oncology, Inc 54 New $32.24 $26,076,000 691,114 0.48% 26,076,000 691,114 1.047    N/A
   (DYN)1 Year Chart         DYN Dyne Therapeutics, Inc. 55 - $29.99 $25,446,000 708,400 0.47% 447,000 0 0.614    N/A
   (CCCC)1 Year Chart         CCCC C4 Therapeutics, Inc. 56 - $0.00 $24,954,000 4,377,900 0.46% 17,964,000 2,864,842 6.314    N/A
   (MLYS)1 Year Chart         MLYS Mineralys Therapeutics, Inc. 57 - $0.00 $24,256,000 2,002,939 0.44% 605,000 -18,485 4.028    N/A
   (NPCE)1 Year Chart         NPCE Neuropace Inc 58 - $9.19 $23,742,000 3,406,335 0.43% -2,010,000 0 14.024    N/A
   (IMTX)1 Year Chart         IMTX Immatics N.V 59 - $7.80 $22,893,000 2,006,381 0.42% -421,000 0 1.946    N/A
   (RYTM)1 Year Chart         RYTM Rhythm Pharmaceuticals, Inc. 60 - $59.36 $22,837,000 435,900 0.42% -6,104,000 -268,942 0.615    N/A
   (PRLD)1 Year Chart         PRLD Prelude Therapeutics Inc 61 - $0.00 $22,582,000 10,909,256 0.41% -18,982,000 0 24.964    N/A
   (APGE)1 Year Chart         APGE Apogee Therapeutics, Inc. 62 - $45.04 $22,270,000 379,130 0.41% 7,351,000 0 0.648    N/A
   (NMRA)1 Year Chart         NMRA Neumora Therapeutics, Inc. 63 - $9.79 $19,815,000 1,500,000 0.36% 5,070,000 0 0.982    N/A
   (SLRN)1 Year Chart         SLRN Acelyrin, Inc. 64 - $4.43 $19,728,000 4,001,711 0.36% 2,080,000 0 4.117    N/A
   (CRBP)1 Year Chart         CRBP Corbus Pharmaceuticals Hold... 65 New $16.08 $18,826,000 912,552 0.34% 18,826,000 912,552 0.728    N/A
   (TYRA)1 Year Chart         TYRA Tyra Biosciences, Inc. 66 - $0.00 $18,071,000 768,638 0.33% 5,780,000 0 1.457    N/A
   (CGEM)1 Year Chart         CGEM Cullinan Oncology Ord Shs 67 - $0.00 $17,913,000 1,070,055 0.33% -2,102,000 -77,600 0.246    N/A
   (LXRX)1 Year Chart         LXRX Lexicon Pharmaceuticals Inc 68 - $0.81 $17,308,000 11,024,000 0.32% 7,487,000 5,177,900 3.05    Diagnostic Substances
   (GPCR)1 Year Chart         GPCR Structure Therapeutics Inc. 69 - $32.71 $16,841,000 383,705 0.31% 11,932,000 258,705 0.64    N/A
   (ACET)1 Year Chart         ACET Adicet Bio, Inc 70 - $0.97 $16,484,000 11,447,140 0.3% 2,633,000 0 13.892    N/A
   (MEDP)1 Year Chart         MEDP Medpace Holdings, Inc. 71 New $326.09 $14,988,000 44,900 0.27% 14,988,000 44,900 0.127    N/A
   (ADCT)1 Year Chart         ADCT ADC Therapeutics Sa 72 - $1.98 $14,281,000 4,533,801 0.26% 640,000 216,977 6.41    N/A
   (GILD)1 Year Chart         GILD Gilead Sciences Inc 73 New $88.63 $12,719,000 151,700 0.23% 12,719,000 151,700 0.012    Biotechnology
   (BNTX)1 Year Chart         BNTX Biontech Se Adr 74 New $0.00 $12,233,000 103,000 0.22% 12,233,000 103,000 0.043    N/A
   (ACAD)1 Year Chart         ACAD Acadia Pharmaceuticals Inc 75 New $16.27 $11,760,000 764,600 0.22% 11,760,000 764,600 0.476    Biotechnology
   (RPTX)1 Year Chart         RPTX Repare Therapeutics Inc. 76 - $0.00 $11,429,000 3,322,488 0.21% 465,000 0 9.041    N/A
   (ABCL)1 Year Chart         ABCL Abcellera Biologics Inc. 77 - $0.00 $10,870,000 4,180,768 0.2% -1,505,000 0 1.553    N/A
   (PMVP)1 Year Chart         PMVP Pmv Pharmaceuticals, Inc. 78 - $0.00 $9,648,000 6,475,291 0.18% -842,000 0 11.904    N/A
   (AVTX)1 Year Chart         AVTX Avalo Therapeutics, Inc 79 New $0.43 $9,187,000 967,000 0.17% 9,187,000 967,000 0.861    N/A
   (VSTM)1 Year Chart         VSTM Verastem, Inc. 80 - $3.79 $8,559,000 2,862,448 0.16% 4,002,000 1,333,333 11.345    Biotechnology
   (LYEL)1 Year Chart         LYEL Lyell Immunopharma, Inc. 81 - $1.03 $8,399,000 6,086,001 0.15% -888,000 -319,097 2.506    N/A
   (OSCR)1 Year Chart         OSCR Oscar Health, Inc. 82 New $0.00 $7,458,000 351,618 0.14% 7,458,000 351,618 0.146    N/A
   (BCAX)1 Year Chart         BCAX Bicara Therapeutics Inc. 83 New $18.38 $6,926,000 271,910 0.13% 6,926,000 271,910 0.5    N/A
   (PASG)1 Year Chart         PASG Passage Bio, Inc. 84 - $0.51 $6,876,000 9,822,876 0.13% -1,165,000 -301,700 21.575    N/A
   (PEPG)1 Year Chart         PEPG Pepgen Inc. 85 New $4.40 $6,817,000 797,358 0.12% 6,817,000 797,358 2.447    N/A
   (NKTX)1 Year Chart         NKTX Nkarta, Inc. 86 - $0.00 $6,692,000 1,480,600 0.12% 1,964,000 680,600 2.098    N/A
   (IKNA)1 Year Chart         IKNA Ikena Oncology, Inc. 87 - $0.00 $6,123,000 3,539,358 0.11% 283,000 0 7.334    N/A
   (FOLD)1 Year Chart         FOLD Amicus Therapeutics Inc 88 - $10.61 $6,091,000 570,300 0.11% 434,000 0 0.168    Biotechnology
   (SRRK)1 Year Chart         SRRK Scholar Rock Holding Corp 89 - $27.86 $5,946,000 742,300 0.11% -3,004,000 -332,082 0.857    N/A
   (FATE)1 Year Chart         FATE Fate Therapeutics Inc 90 - $2.22 $5,882,000 1,680,580 0.11% 1,436,000 325,228 1.013    Biotechnology
   (NSPR)1 Year Chart         NSPR Inspiremd, Inc 91 - $0.00 $5,718,000 2,133,405 0.1% 395,000 0 9.9    N/A
   (LBPH)1 Year Chart         LBPH Longboard Pharmaceuticals, ... 92 New $0.00 $5,666,000 170,000 0.1% 5,666,000 170,000 0.437    N/A
   (TELA)1 Year Chart         TELA Tela Bio, Inc. 93 - $2.90 $5,468,000 2,161,185 0.1% -6,082,000 -296,357 8.825    N/A
   (XFOR)1 Year Chart         XFOR X4 Pharmaceuticals Inc 94 - $0.34 $4,774,000 7,133,515 0.09% 637,000 0 4.264    N/A
   (KRYS)1 Year Chart         KRYS Krystal Biotech Inc 95 - $178.10 $4,278,000 23,500 0.08% -1,225,000 -6,466 0.082    N/A
   (ARDT)1 Year Chart         ARDT Ardent Health Partners, Inc. 96 New $16.44 $3,786,000 206,000 0.07% 3,786,000 206,000 0.144    N/A
   (TRAW)1 Year Chart         TRAW Traws Pharma, Inc 97 - $4.49 $3,561,000 605,531 0.07% 3,094,000 -439,730 12.111    N/A
   (MIST)1 Year Chart         MIST Milestone Pharmaceuticals Inc. 98 - $0.00 $3,040,000 2,000,000 0.06% 400,000 0 3.022    N/A
   (CMMB)1 Year Chart         CMMB Chemomab Therapeutics Ameri... 99 - $0.00 $2,734,000 1,741,273 0.05% 689,000 -500,000 25.532    N/A
   (TIL)1 Year Chart         TIL Instil Bio Ord Shs 100 New $0.00 $2,269,000 33,700 0.04% 2,269,000 33,700 0.026    N/A

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